This Uruguay 4-4-2 is bad. Getting out played by Saudi Arabia in midfield as it's 3v2, and neither Cavani or Suarez drop deep to support. Also I don't think it helps that the wide players are 32 and 33 years old.
Seems like they're playing this way just to have Suarez and Cavani up front together, but I think they'd do much better playing a 4-3-3 and pushing one out wide, or even having some rotation between who is wide and who's through the middle to cause more problems. 4-3-3 would mean getting Torreira in midfield and they'd find retaining possession so much easier.